Lab Members

Al Charest, M.Sc., Ph.D.

Cancer Research Institute, Cancer Genetics Program

Beth Israel Deaconess Medical Center


Department of Medicine, Division of Genetics, Harvard Medical School



Dr. Charest obtained his B.Sc. in Biochemistry, M.Sc. in Pharmacology and his Ph.D. in Biochemistry at McGill University, Montreal, Canada. He then pursued Postdoctoral studies at the Center for Cancer Research at the Massachusetts Institute of Technology, Cambridge, MA, USA.

Postdoctoral Fellows

Hyun Jung Jun

Aron Gyuris, Ph.D.

Education:   B.Sc. in Biology, Incheon National University 

                      M.Sc in Molecular Cancer Biology, Incheon National University 


Research Projects: Characterization of PTEN mutants in glioblastoma

Contact: hjun at bidmc dot harvard dot edu

Education:      B.A. in Biology, Brown University (2004)

                         Ph.D. in Molecular Biology, Cell Biology and Biochemistry,

                         Brown University (2014)


Research Projects: Extracellular vesicles (EVs) are emerging as a novel mechanism of intracellular communication in normal development, homeostasis and various disease states.  A wide range of EVs from distinct biogenetic origins are shed from donor cells and carry characteristic cargoes of proteins, nucleic acids and lipids to exert distal functions in recipient cells.  In the Charest lab, we use cell lines derived from a mouse model of glioblastoma driven by EGFR overexpression to study the how the RNA content of EVs change in the background of EGFR inhibition in an effort to understand how EV content can be used as indicators of disease and potential efficacy of therapies.

Contact: agyuris at bidmc dot harvard dot edu

Bethany Delcuze

Education:        B.S. in Biology, Loyola University Maryland (2012)

                           Current Student in Cellular and Molecular Physiology, Tufts  

                          University Sackler School of Biomedical Sciences


Research Projects: I work on tumor associated macrophages and tissue resident microglia which are associated with poor prognosis in glioblastoma. I am working to elucidate the role of the CDKN2A locus in modulating the tumor supportive phenotype commonly found in these tumor associated macrophages/microglia.

Contact: bethany.delcuze at tufts dot edu

               bdelcuze at bidmc dot harvard dot edu

Alan Yeo

Education:          BA in Biochemistry & Molecular Biology (2011) 

                              MA in Biotechnology (2011) 

                              Boston University. 

                         

Research Projects: Checkpoint blockade in genetically engineered mouse models of EGFR-driven glioblastoma.


Contact: ayeo at bidmc dot harvard dot edu

               alan.yeo at tufts dot edu

Principal Investigator

Graduate Students