Signaling in Cancer
Our lab focuses on oncogenic signaling pathways emanating from the epidermal growth factor receptor (EGFR) and the platelet derived growth factor receptor alpha (PDGFRAA). These cell surface receptors are the most commonly mutated genes in primary brain cancer and we have demonstrated that dysregulation of these receptors are oncogenic.
We are investigating the molecular mechanisms by which these receptors regulate brain cancer initiation, progression and resistance to therapy. To achieve this, we take multiple approaches including proteomics and phosphoproteomics mass spectrometry-based analyses, single cell RNA sequencing, bioinformatics and state of the art genetic engineering mouse modeling of primary brain cancer.