Signaling in Cancer

Our lab focuses on oncogenic signaling pathways emanating from the epidermal growth factor receptor (EGFR) and the platelet derived growth factor receptor alpha (PDGFRAA). These cell surface receptors are the most mutated genes in primary brain cancer and we have demonstrated that dysregulation of these receptors are oncogenic.

We are investigating the molecular mechanisms by which these receptors regulate brain cancer initiation and progression.  To achieve this, we are taking multiple approaches including proteomics and phosphoproteomics mass spectrometry-based analyses, bioinformatics and state of the art genetic engineering mouse modeling of primary brain cancer.